Dengue Virus Envelope Protein Structure and Topography

In the Baric lab we study the structure of dengue virus to understand how it infects people, and how our immune system attacks it. To better understand the structure of the dengue virus, we can use 3D models of dengue proteins to predict how they will interact with other dengue proteins, and with our immune system. Our 3D model of the protein that covers the dengue virus allowed us to gain insights into the structure that weren’t obvious from 2D models.
-Ralph Baric, Baric Lab, UNC School of Medicine and the UNC Gillings School of Global Public Health and Emily Gallichotte